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Meta-analysis of cross-over trials
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Heather Dickinson, Marta Roqué i Figuls
Objectives: To provide review authors with the knowledge and skills that they need to extract data from reports of cross-over trials and include such data in a meta-analysis.
Summary: The workshop will discuss randomized controlled trials with a two-period, two-treatment cross-over design such that each participant in the trial receives both treatments. It will focus primarily on continuous outcomes and will cover:
- what is a cross-over trial;
- why include cross-over trials in a meta-analysis;
- problems with cross-over trials;
- combining parallel and cross-over trials in a meta-analysis;
- carry over effects;
- practical issues of data extraction for cross-over trials.
The issues will be illustrated with practical work extracting data from papers. Participants should bring calculators, highlighter pens, and a laptop if they have one (laptops should be fully charged as there will be no power supply available at the workshop).
Level of knowledge required to attend: advanced.
Dublin 2006 -- W42