To assess the effects of radiation therapy for preventing instrumentation track metastases in malignant pleural mesothelioma.

Secondary objectives include to determine:

• the true incidence of instrumentation track metastases in contemporary MPM patient populations;
• the impact of patient characteristics (e.g. histological subtype of MPM) and intervention characteristics (e.g. maximally invasive versus minimally invasive) on the risk of developing instrumentation track metastases;
• the impact of radiation treatment on secondary patient outcomes such as quality of life, survival time, and disease-free interval; and
• the incidence of irradiation-induced dermatitis in MPM patients receiving prophylactic radiotherapy.