This is a protocol for a Cochrane Review (intervention). The objectives are as follows:
Primary objective:
-
to assess the benefits and harms of currently recommended regimens as the first-line therapy in high-risk people with chronic lymphocytic leukemia, using network meta-analysis
Secondary objectives:
-
to assess whether the benefits and harms of the recommended regimens differ according to sex, Rai stage, or genetic mutation status
-
to estimate the ranking of treatments for overall survival, progression-free survival, objective response rate , complete response rate, minimal residual disease, and serious adverse events
-
to estimate the overall rate of adverse events and serious adverse events
This is a protocol.