First-line therapy for high-risk people with chronic lymphocytic leukemia: a network meta-analysis

This is a protocol for a Cochrane Review (intervention). The objectives are as follows:

Primary objective:

  • to assess the benefits and harms of currently recommended regimens as the first-line therapy in high-risk people with chronic lymphocytic leukemia, using network meta-analysis

Secondary objectives:

  • to assess whether the benefits and harms of the recommended regimens differ according to sex, Rai stage, or genetic mutation status

  • to estimate the ranking of treatments for overall survival, progression-free survival, objective response rate , complete response rate, minimal residual disease, and serious adverse events

  • to estimate the overall rate of adverse events and serious adverse events

This is a protocol.