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Dual combination therapy versus long-acting bronchodilators alone for chronic obstructive pulmonary disease (COPD): a systematic review and network meta-analysis

This is a protocol for a Cochrane Review (intervention). The objectives are as follows:

To assess the comparative efficacy and safety of fixed-dose dual inhalers (i.e. LABA/LAMA versus ICS/LABA) and combination therapies versus LABA or LAMA monotherapy in individuals with moderate to very severe COPD, using network meta-analysis, and to rank these treatments based on their efficacy and safety.

This is a protocol.

Published:

3 April 2025

Authors:

Oba Y, Pathak M, Maduke T, Fakhouri EW, Dias S

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Oba Y, Pathak M, Maduke T, Fakhouri EW, Dias S. Dual combination therapy versus long-acting bronchodilators alone for chronic obstructive pulmonary disease (COPD): a systematic review and network meta-analysis (Protocol). Cochrane Database of Systematic Reviews 2025, Issue 4. Art. No.: CD015997. DOI: 10.1002/14651858.CD015997.