This is a protocol for a Cochrane Review (intervention). The objectives are as follows:

Primarily, to determine the effectiveness of a virtual reality (VR) intervention compared to an alternative or no intervention for people living with advanced cancer:

• on pain intensity, adverse events (AEs) and serious adverse events (SAEs); and secondarily,

• on additional pain properties (e.g. type, frequency), psychological well-being, other physical symptoms (e.g. anxiety) and quality of life.

We will also report on the context in which the VR was implemented (setting, type and dose of VR).