Peter Sandercock from the University of Edinburgh in Scotland tells us how two randomised trials, with 40,000 patients in more than 800 hospitals, changed clinical practice for tens of millions of people with a stroke.

This podcast is part of the Trials Change Lives initiative, developed by the MRC Network of Hubs for Trials Methodology Research in partnership with the Northern Ireland Network for Trials Methodology Research. Free posters are available to download methodologyhubs.mrc.ac.uk/research/trials-change-lives.